Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
BUCLIZINE
CAS: 82-95-1
Molecular Formula: C28H33ClN2
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- - Names and Identifiers
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- - Physico-chemical Properties
| Molecular Formula | C28H33ClN2 |
| Molar Mass | 433.03 |
| Density | 0.9970 (rough estimate) |
| Boling Point | bp0.001 217-220° |
| Storage Condition | -20°C |
| Refractive Index | 1.5940 (estimate) |
| Physical and Chemical Properties | Chemical Properties White Powder Crystallization. Melting point 230-240 ℃(221-225 ℃). Insoluble in water, soluble in ethanol and chloroform, boiling point 217-220 ℃(0.13 3千帕). Its hydrochloride (C28H33CIN2 · 2HCI = 505.98) is also called Anjimin, with a melting point of 265-266 ℃. |
| Use | Use Anti-allergic drugs. Can be used for urticaria, neurodermatitis, etc. It can also be used for pregnancy vomiting and motion sickness. |
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- - Upstream Downstream Industry
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- - Uses and synthesis methods
overview
The chemical formula of bukrizine compound is 1-(p-tert-butylbenzyl)-4-(p-chlorobenzyl) piperazine, which is clinically used as a piperazine antihistamine, The antihistamine effect is stronger and longer than diphenhydramine, the antiemetic effect is also significantly longer, and it has a stable and anti-anxiety effect.
Indications
bukrizine is used for acute or chronic urticaria, eczema, dermatitis and other allergic skin diseases. It can also be used for motion sickness, insomnia, anxiety, etc.
Production method
Using tert-butanol as a raw material, in the presence of aluminum trichloride, it reacts with benzene to form tert-butadiene benzene, and uses paraformaldehyde, hydrochloric acid, etc. for chloromethylation reaction to form p-tert-butylbenzyl chloride, and then Condensation with piperazine to form p-tert-butylbenzylpiperazine hydrochloride, neutralize with alkali to obtain p-tert-butylbenzylpiperazine, and condensation with p-chlorodiphenylbromomethane to form chlorphenazine. Chlorbenzine hydrochloride is generated.
Last Update：2024-04-10 22:29:15
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CAS: 82-95-1
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CAS: 82-95-1
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View History
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
Potssium silicate
Potssium silicate
Raw Materials for Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
Paraformaldehyde
tert-Butylbenzene
1-Benzylpiperazine
4-Chlorobenzhydrylchloride
Ethyl N-piperazinecarboxylate
4-tert-Butylbenzyl chloride
1-(4-Chlorobenzhydryl)piperazine
1-(4-TERT-BUTYLBENZYL)PIPERAZINE
BUCLIZINE, DIHYDROCHLORIDE
tert-Butylbenzene
1-Benzylpiperazine
4-Chlorobenzhydrylchloride
Ethyl N-piperazinecarboxylate
4-tert-Butylbenzyl chloride
1-(4-Chlorobenzhydryl)piperazine
1-(4-TERT-BUTYLBENZYL)PIPERAZINE
BUCLIZINE, DIHYDROCHLORIDE